Version: 1.0.0 | Published: 8 Oct 2024 | Updated: 229 days ago
Summary
DOI Name:
10.1136/bmjresp-2019-000439
Documentation
Associated Media:
Description:
The It"s Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS) is a multicentre, prospective, observational cohort study. The aims of this study are to identify genetic, serum and other biomarkers that may identify specific molecular mechanisms, reflecting disease endotypes that are shared among patients with progressive pulmonary fibrosis regardless of aetiology. Furthermore, it is anticipated that these biomarkers will help predict fibrotic activity that may identify patterns of disease behaviour with greater accuracy than current clinical phenotyping.
200 participants with the multidisciplinary team confirmed fibrotic lung disease (50 each of rheumatoid-interstitial lung disease (ILD), asbestosis, chronic hypersensitivity pneumonitis and unclassifiable ILD) and 50 idiopathic pulmonary fibrosis participants, recruited as positive controls, will be followed up for 2 years. Participants will have blood samples, lung function tests, quality of life questionnaires and a subgroup will be offered bronchoscopy. Participants will also be given the option of undertaking blinded home handheld spirometry for the first 3 months of the study. The primary end point will be identification of a biomarker that predicts disease progression, defined as 10% relative change in forced vital capacity (FVC) or death at 12 months.
Coverage
Spatial:
United Kingdom
Typical Age Range:
15-150
Follow Up:
1 - 10 Years
Pathway:
Study
Provenance
Origin
Sources:
Other
Temporal
Accrual Periodicity:
Annual
Distribution Release Date:
06 April 2019
Start Date:
11 November 2018
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
In Progress
Access Service:
Enquiries to SAIL Databank or INJUSTIS team
Delivery Lead Time:
Not applicable
Data Controller:
BREATHE
Data Processor:
BREATHE
Usage
Data Use Limitations:
General research use
Data Use Requirements:
Project-specific restrictions
Resource Creators:
University of Nottingham
Format and Standards
Vocabulary Encoding Schemes:
- LOCAL
- NHS NATIONAL CODES
Languages:
en