Version: 1.0.0 | Published: 8 Oct 2024 | Updated: 229 days ago
Summary
DOI Name:
10.1136/bmjopen-2020-039097
Documentation
Description:
Introduction: Following the emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 and the ensuing COVID-19 pandemic, population-level surveillance and rapid assessment of the effectiveness of existing or new therapeutic or preventive interventions are required to ensure that interventions are targeted to those at highest risk of serious illness or death from COVID-19. We aim to repurpose and expand an existing pandemic reporting platform to determine the attack rate of SARS-CoV-2, the uptake and effectiveness of any new pandemic vaccine (once available) and any protective effect conferred by existing or new antimicrobial drugs and other therapies.
Methods and analysis: A prospective observational cohort will be used to monitor daily/weekly the progress of the COVID-19 epidemic and to evaluate the effectiveness of therapeutic interventions in approximately 5.4?million individuals registered in general practices across Scotland. A national linked dataset of patient-level primary care data, out-of-hours, hospitalisation, mortality and laboratory data will be assembled. The primary outcomes will measure association between: (A) laboratory confirmed SARS-CoV-2 infection, morbidity and mortality, and demographic, socioeconomic and clinical population characteristics; and (B) healthcare burden of COVID-19 and demographic, socioeconomic and clinical population characteristics. The secondary outcomes will estimate: (A) the uptake (for vaccines only); (B) effectiveness; and (C) safety of new or existing therapies, vaccines and antimicrobials against SARS-CoV-2 infection. The association between population characteristics and primary outcomes will be assessed via multivariate logistic regression models. The effectiveness of therapies, vaccines and antimicrobials will be assessed from time-dependent Cox models or Poisson regression models. Self-controlled study designs will be explored to estimate the risk of therapeutic and prophylactic-related adverse events.
https://bmjopen.bmj.com/content/10/6/e039097
Coverage
Spatial:
United Kingdom,Scotland
Typical Age Range:
0-150
Provenance
Temporal
Accrual Periodicity:
Monthly
Start Date:
01 January 1970
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
Delivery Lead Time:
Not applicable
Data Controller:
EAVEII team
Data Processor:
EAVEII team
Usage
Resource Creators:
Public Health Scotland
Format and Standards
Vocabulary Encoding Schemes:
- READ
- ICD10
Languages:
en
Formats:
- Excel Files
- R Files