Version: 1.0.0 | Published: 8 Oct 2024 | Updated: 228 days ago
Documentation
Associated Media:
Description:
The Genetics of Asthma Severity & Phenotypes initiative was set up in 2013 as part of an Asthma UK funded programme of work to directly address the need for a large cohort of moderate-severe asthma patients for genetic studies.
The cohort was established by bringing together all of the major respiratory centres across the UK to provide access to existing samples/clinical data but also to prospectively recruit patients (still ongoing). This cohort has been utilised in our recent GWAS of Moderate-Severe asthma (PMID: 30552067).
The cohort is currently ~4,000 individuals and to date 2,536 individuals have Affymetrix Axion array data that has completed QC imputed to provide 33M variants. The cohort has extensive clinical and immunological data although absolute numbers of these measures are variable due to the nature of the formation of the cohort.
Coverage
Spatial:
United Kingdom
Typical Age Range:
0-150
Follow Up:
1 - 10 Years
Provenance
Temporal
Accrual Periodicity:
Annual
Distribution Release Date:
12 January 2019
Start Date:
01 January 2013
End Date:
01 January 2020
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
Access Request Cost:
Data provision is free from SAIL. Overall project costing depends on the number
of people that require access to the SAIL Gateway, the activities that SAIL
needs to complete (e.g. loading non-standard datasets), data refreshes,
analytical work required, disclosure control process, and special case
technological requirements
Delivery Lead Time:
Not applicable
Data Controller:
BREATHE
Data Processor:
BREATHE
Usage
Data Use Limitations:
General research use
Resource Creators:
University of Nottingham
Format and Standards
Vocabulary Encoding Schemes:
- LOCAL
- NHS NATIONAL CODES
Languages:
en
Formats:
CSV