Version: 1.0.0 | Published: 10 Nov 2026 | Updated: 0 days ago
Documentation
Description:
HOW TO REQUEST ACCESS - complete these steps BEFORE starting an access request here. (1) Create an account on the RADC Research Resource Sharing Hub (https://www.radc.rush.edu/account/account.htm), or log in, and submit a data request on the Requests page (https://www.radc.rush.edu/requests.htm). In section 8, "Other Information", state that you are requesting the "ROSMAP Plasma Proteomics (SomaScan v4.1)" dataset on the ADDI AD Workbench. List the PI and every collaborator who will access the data. All files are shared together, so there is no need to choose parts of the dataset. RADC issues a request number. (2) Execute the RADC Data Use Agreement (DUA) with RADC. (3) Once the DUA is fully executed, submit the access request here with the RADC request number, the PI name and the collaborator names exactly as they appear on the DUA. The RADC omics coordinator checks them against the DUA on file at RADC and approves the request. Requests without an executed DUA cannot be approved. ABOUT THE DATA - Plasma proteomics from the Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP), generated with the SomaScan Multiplex Aptamer Assay v4.1 (SomaLogic, Inc., Boulder, CO, USA; 55 uL EDTA plasma per assay). The release has three components: (1) 01_harmonized_ComBat - a harmonized dataset combining published ROSMAP plasma SomaScan runs: 1,611 samples from 1,313 participants with plasma collected during life and post-mortem neuropathology (mean years from visit to death 5.30 +/- 3.84). Samples were restricted to RowCheck = PASS, ANML-normalized data from SomaLogic were used, and ComBat removed residual batch effects. Includes a protein abundance matrix, protein (aptamer) annotation, sample annotation, and the 102 ROSMAP phenotypes used in the blood-phenome study (demographics, genetics, cognition, clinical diagnoses, motor function, medications and neuropathology), one row per plasma sample. (2) 02_source_Rush_SS-2216331 - the SomaLogic delivery for project SS-2216331 (ROS EDTA plasma), including ADAT files with and without ANML normalization, SomaSignals, the SQS report and the corrected sample manifest with projid and follow-up year. (3) 03_source_Stanford_SS-2337854 - the SomaLogic delivery for project SS-2337854, including ADAT files, CSV exports of sample metadata/expression and protein metadata, and the SQS report. Other ROSMAP variables can be requested from RADC in the same request (variable documentation: https://www.radc.rush.edu/docs/documentation.htm). Generation of ROSMAP SomaScan data was supported by Gates Ventures, Johnson & Johnson, and the Phil and Penny Knight Initiative for Brain Resilience.
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
See dataset for details. Access data at: https://discover.alzheimersdata.org/catalogue/datasets/28295904-0ced-47a1-b047-ff5647099138
Access Service:
Delivery Lead Time:
Variable
Usage
Resource Creators:
Shinya Tasaki
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Events
1313
Count
01 January 2026