Version: 1.0.0 | Published: 15 Oct 2026 | Updated: 0 days ago
Documentation
Description:
Recent work has identified roles for environmental, genetic and epigenetic factors in AD risk. Motivated by suspected roles for epigenetic modifications in AD, we performed (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76105) a genome-wide screen of DNA methylation using the Illumina Infinium HumanMethylation450 array platform on bulk tissue samples from the superior temporal gyrus (STG) of AD cases and non-demented controls. We paired a sliding window approach with linear models that account for age, gender, ethnicity, and estimated cellular proportions (neuronal vs. glial), to characterize AD-associated differentially methylated regions (DMRs).
Whole DNA was extracted from STG tissue dissections collected from deceased individuals with and without Alzheimers Disease. DNA was bisulfite converted and global DNA methylation levels were assessed using Illumina Infinium HumanMethylation450 BeadChip.
Platform: GPL13534 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GPL13534)
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
See dataset for details. Access data at:
Usage
Resource Creators:
GSE76105
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
68
Count
01 January 2026