Version: 1.0.0 | Published: 5 Oct 2026 | Updated: 0 days ago
Documentation
Description:
**Experiment type**: Expression profiling by high throughput sequencing
**Summary**: This project aims to characterize the distribution of “big tau,” a longer tau isoform expressed in the peripheral nervous system (PNS) and select central nervous system (CNS) regions, and to examine its relationship with aging and neurodegeneration. We performed mass spectrometric sequencing of big tau sequence and mapped its distribution across the human nervous system. Postmortem samples included brains from Alzheimer’s disease (AD), disease controls, and amyotrophic lateral sclerosis (ALS); spinal cord from young controls, disease controls and ALS; and peripheral nerves. Big and small tau levels were also quantified in the cerebrospinal fluid (CSF) from young normal controls, amyloid positive and amyloid negative participants. To reinforce the presence of big tau in the brain, iso-seq was performed on post-mortem brain tissue samples.
**Overall design**:MAPT-focused iso-seq was performed on five caudate and five middle frontal gyrus post-mortem frozen brain tissue samples from individual control donors with European ancestry.
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
See dataset for details. Access data at:
Usage
Resource Creators:
Alison Goate;,;Joshua Orrick
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
0
Count
01 January 2026