Documentation
Description:
A key achievement of the European Prevention of Alzheimer"s Dementia (EPAD) project (http://ep-ad.org/) was the establishment of a Longitudinal Cohort Study (LCS) that has screened a total of 2,096 participants from 31 study sites in 10 European countries. A wide range of cognitive, clinical, neuroimaging, and biomarker data were collected, thus generating a comprehensive and large data set to help further our understanding of the early stages of Alzheimer’s disease. The LCS was initiated and the first participant screened in May 2016. Screening into the LCS was stopped on 29 February 2020. The final dataset presented here is called Version.IMI (V.IMI) as it represents all the data collected and processed during the period the project was funded by the Innovative Medicines Initiative (IMI) (https://www.imi.europa.eu/).
Following approval to access EPAD data, the user can transfer the v.IMI files to their workspace. Genomic data files however are not accessed in the same way. The EPAD Genomics Shared Drive will be linked to the user’s workspace Virtual Machine.
Genome-wide genotyping was performed on 1,983 participant samples assaying 713,127 SNPs across the autosomes. PLINK-formatted files of pre-QC’d data are available, as are subsets of the data filtered for quality, ancestry and relatedness. Pairwise relatedness was calculated across all participants and the relatedness table is available. Finally, three independent imputation analyses were performed using the HRC, 1000Genomes and TOPMed imputation panels, respectively. Please see the files in the Related Documents section for more details on the genomics data.
The imaging data from this study can be requested here (EPAD LCS v.IMI (Imaging)) (https://discover.alzheimersdata.org/catalogue/datasets/54fd86a7-cc1a-4ac0-b9c9-41bafc98a9f5)
The biosample collection from this study can be requested here (EPAD LCS v.IMI (Biosamples)) (https://discover.alzheimersdata.org/catalogue/datasets/aeff6407-00fa-4d63-bce4-36d7668d19e4)
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
See dataset for details. Access data at:
Usage
Resource Creators:
EPAD Longitudinal Cohort Study
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
2096
Count
01 January 2026