Version: 1.0.0 | Published: 24 Sep 2026 | Updated: 0 days ago
Documentation
Description:
The Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic and Natural History Study (PNHS) is an open-label, prospective, multicentre, cohort study linked to a variety of European Parent Cohorts.
AMYPAD PNHS aims to improve disease modelling efforts and individualized risk stratification within the context of Alzheimer"s disease, by the additional collection of amyloid burden, measured by positron emission tomography (PET) imaging.
The current version of the AMYPAD PNHS dataset integrates information from 10 Parent Cohorts: ALFA+, AMYPAD DPMS, DELCODE, EMIF-AD (60++), EMIF-AD (90+), EPAD LCS, FACEHBI, FPACK, Microbiota, and UCL-2010-412. This dataset includes a total of 3368 participants. Of them, 1620 underwent a baseline amyloid PET that includes the visual read and the Centiloid quantification (1476 subjects), among other metrics. Moreover, 888 participants have (at least) one follow-up PET scan, 763 of them with Centiloid quantification. The participant"s clinical outcomes (e.g., cognition), disease (imaging) biomarkers, risk factors (e.g., genetics and environmental), and other relevant variables are included in the dataset.
Moreover, this version of the dataset includes only the "harmonized" and "derived" set of variables (further details can be found in the Data Access Request Procedure documents attached below).
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
Restricted Access. Access data at: https://fair.addi.ad-datainitiative.org/#/data/datasets/amypad_pnhs__harmonised_and_derived__v202306/request/catalog-dar
Usage
Resource Creators:
David Vállez García
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
3368
Count
01 January 2026