Documentation
Description:
The Dominantly Inherited Alzheimer Network Observational (DIAN Obs) study enables researchers around the world to monitor and identify changes in individuals who carry one of the gene mutations (Presenilin1, Presenilin2 or APP) known to cause dominantly inherited Alzheimer’s disease (DIAD).
DIAN Obs studies the development of dominantly inherited AD in verified mutation carriers in comparison with their non-carrier siblings, who serve as a naturally occurring control group. All DIAN Obs participants are assessed longitudinally with comprehensive and state-of-the-art clinical, cognitive, genetic, imaging, and biomarker protocols, and all data are collected in a standard and uniform manner for entry into a central repository.
Required documents for the data access request can be downloaded from the **Related Documents** section below.
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
See dataset for details. Access data at:
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
717
Count
01 January 2026