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Version: 1.0.0 | Published: 24 Sep 2026 | Updated: 0 days ago

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Dataset

Documentation

Description:
Coordinated transcriptomic and proteomic studies of TDP-43 depleted iPSC-derived neurons to identify numerous peptides that mapped to cryptic exons. Mis-spliced proteins identified in iPSC neurons were verified in human ALS/FTD CSF and brain samples. Here, we provide the files used in the ribosome sequencing, mass spectrometry, proteomics, and long read RNA sequencing analyses for this study

Coverage

Spatial:
US
Follow Up:
Unknown

Provenance

Temporal

Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable

Accessibility

Access

Access Rights:

Usage

Resource Creators:
Mike Nalls, Laurel Screven

Observations

Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
15
Count
01 January 2026