Version: 1.0.0 | Published: 23 Sep 2026 | Updated: 0 days ago
Documentation
Description:
Examination of the miRNA profile in blood samples of 48 AD patients and 22 controls - GSE46579 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE46579)
We applied Next-Generation Sequencing (NGS) to miRNAs from blood samples of 48 AD (Alzheimer"s Disease) patients and 22 unaffected controls, yielding a total of 140 unique mature miRNAs with significantly changed expression level. Of these, 82 were higher and 58 lower abundant in samples from AD patients. We selected a panel of 12 miRNAs for a qRT-PCR analysis on a larger cohort of 202 samples including not only AD patients and healthy controls but also patients with other CNS illnesses: Multiple Sclerosis, Parkinson"s Disease, Major Depression, Bipolar Disorder, Schizophrenia, and Mild Cognitive Impairment, which is assumed to represent a transitional period before the development of AD. MiRNA target enrichment analysis of the selected 12 miRNAs indicated an involvement of miRNAs in nervous system development, neuron projection, neuron projection development, and neuron projection morphogenesis, respectively. Using this 12-miRNA signature we were able to differentiate between AD and controls with an accuracy of 93.3%, a specificity of 95.1%, and a sensitivity of 91.5%. The differentiation of AD from other neurological diseases was possible with accuracies between 73.8% and 77.8%. The differentiation of the other CNS disorders from controls yielded even higher accuracies.
Platform: GPL11154 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GPL11154)
SRA: SRP022043 (https://www.ncbi.nlm.nih.gov/sra?term=SRP022043)
Coverage
Spatial:
US
Follow Up:
Unknown
Provenance
Temporal
Accrual Periodicity:
Static
Start Date:
01 January 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
See dataset for details. Access data at:
Usage
Resource Creators:
GSE46579
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
70
Count
01 January 2026