Version: 1.0.0 | Published: 8 Oct 2024 | Updated: 226 days ago
Documentation
Description:
Lactate is a chemical produced by the body as cells consume energy - in times of stress more lactate is produced. In the past, we thought that lactate was just a waste product, but more recently we have learned that lactate has an important role to play in the body.
People suffering from certain severe illnesses may have a high ‘lactate’ level in their blood. This is particularly common in the following:
Severe infections which the body cannot properly control (sepsis)
People who have sustained severe injuries (traumatic injury)
People who are critically unwell with other illnesses (needing treatment in an intensive care unit)
Some patients will develop a high lactate level when they are in hospital. Doctors recognise that this indicates the patient is becoming more unwell, but it is often challenging to know exactly what is causing the lactate level to be raised.
Raised lactate level has been associated with worse outcome in other syndromes, including major trauma and undifferentiated critical illness; however healthy individuals may generate very high lactate levels during strenuous exercise from which they recover without any harm. It is unclear whether lactate in itself is harmful to patients. This dataset provides unique insight into the potential role of lactate as not only a biomarker but a therapeutic target in acute illness.
PIONEER geography The West Midlands (WM) has a population of 5.9 million and includes a diverse ethnic and socio-economic mix.
EHR. UHB is one of the largest NHS Trusts in England, providing direct acute services and specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds and an expanded 250 ITU bed capacity during COVID. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary and secondary care record (Your Care Connected) and a patient portal “My Health”.
Scope: Longitudinal and individually linked, so that the preceding and subsequent health journey can be mapped and healthcare utilisation prior to and after admission understood. The dataset includes highly granular patient demographics, co-morbidities taken from ICD-10 and SNOMED-CT codes. Serial, structured data pertaining to process of care (timings, admissions, wards), presenting complaint, physiology readings (BMI, temperature and weight), Sample analysis results (blood sodium level, lactate, haemoglobin, oxygen saturations, and others) drug administered and all outcomes.
Available supplementary data: Matched controls; ambulance, OMOP data, synthetic data.
Available supplementary support: Analytics, Model build, validation & refinement; A.I.; Data partner support for ETL (extract, transform and load) process, Clinical expertise, Patient and end-user access, Purchaser access, Regulatory requirements, Data-driven trials, “fast screen” services.
Coverage
Spatial:
United Kingdom,England,West Midlands
Typical Age Range:
19-105
Follow Up:
Other
Pathway:
Data is representative of the multi-ethnicity population within the West
Midlands (42% non white). Data includes all patients admitted during this
timeframe, with National data Opt Outs applied, and therefore is representative
of admissions to secondary care. Data focuses on in-patient stay in hospital
during the acute episode but can be supplemented on request to include previous
and subsequent hospital contacts (including outpatient appointments) and
ambulance, 111, 999 data.
Provenance
Origin
Purposes:
Care
Sources:
EPR
Collection Situations:
Secondary care - In-patients
Temporal
Accrual Periodicity:
Quarterly
Distribution Release Date:
25 November 2021
Start Date:
01 January 2018
End Date:
28 December 2020
Time Lag:
Other
Accessibility
Access
Access Service:
Trusted Research Environments (TRE) are built using Microsoft Azure services and
hosted in the UK to provide research teams a safe, secure and agile environment
which allows users to quickly analyse, interpret and form an enriched view of
primary care information through a range of integrated datasets. Health data
collated from multiple sources is ingested into a secure data lake which will
then allow subsets of data to be made available to research teams on approval of
a data request. Once approved a customer specific TRE is made available with a
standard set of leading analytical tools from Microsoft including Azure
Databricks, Azure Machine Learning, Azure SQL and Azure Synapse (for large-scale
data warehouses). Specific tools can be provided at an additional cost over the
standard platform data access charge and the PIONEER team will work with you to
determine your exact needs. Access to the TRE is managed using the latest
virtual desktop technology to provide a safe and secure end-user experience. By
utilising leading edge design PIONEER are able to create TREs rapidly to enable
us to service any customer requirement.
Access Request Cost:
www.pioneerdatahub.co.uk/data/data-services-costs/
Delivery Lead Time:
Not applicable
Jurisdictions:
GB-ENG
Data Controller:
University Hospitals Birmingham NHS Foundation Trust
Usage
Data Use Limitations:
General research use
Data Use Requirements:
Project-specific restrictions
Resource Creators:
This publication uses data from PIONEER, an ethically approved database and analytical environment (East Midlands Derby Research Ethics 20/EM/0158)
Format and Standards
Vocabulary Encoding Schemes:
- SNOMED CT
- ICD10
Conforms To:
LOCAL
Languages:
en
Formats:
SQL
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
12,369 ICU admissions with lactate reading from 01/01/2018 to 31/12/2020
12369
Count
25 November 2021