Version: 1.0.0 | Published: 8 Oct 2024 | Updated: 228 days ago
Documentation
Associated Media:
Description:
A dataset of 552 patients who have been cared for on ICU.
Natriuretic peptides are special proteins produced by the heart, with the two key types being BNP and NT-proBNP. NT-proBNP is particularly useful in managing heart failure and assessing the risk of heart problems. This marker is not just for heart failure; studies have suggested that NT-proBNP levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments in physical function and muscle strength in sepsis survivors.
This dataset includes detailed demographic information, comorbidities and admission reasons and journeys for patients who have required an intensive care admission. The data includes serial physiological and blood test measurements reflecting the severity of the patient’s condition, imaging and other investigative results, treatments, and outcomes. This data is invaluable in identifying the clinical utility of NT-proBNP as a potential prognostic marker for future complications and mortality.
PIONEER geography: The West Midlands (WM) has a population of 6.2 million & includes a diverse ethnic & socio-economic mix.
EHR: UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & an expanded 250 ITU bed capacity during COVID. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health.”
Scope: Patients without chronic heart failure or acute heart failure diagnoses admitted to ICU with sepsis, acute respiratory failure (specifically ARDS) or polytrauma without severe head injury; with at least one measurement of NT-proBNP at any time from 3-months pre-ICU admission to 6 months post-ICU discharge
Longitudinal & individually linked, so that the preceding & subsequent health journey can be mapped & healthcare utilisation prior to & after admission understood. The dataset includes highly granular patient demographics & co-morbidities taken from ICD-10 & SNOMED-CT codes. Serial, structured data pertaining to acute care process (timings, hospital mortality, Length of stays, readmissions), Intensive care details, primary diagnosis, SOFA score & APACHE II scores, NT-proBNP results & outcomes.
Available supplementary data: Matched controls; ambulance, OMOP data, synthetic data.
Available supplementary support: PIONEER can also offer analytics, Model build, validation & refinement; A.I.; Data partner support for ETL (extract, transform & load) process, Clinical expertise, Patient & end-user access, Purchaser access, Regulatory requirements, Data-driven trials, “fast screen” services.
This research is supported by the National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC), specifically the Infections and Acute Care theme.
Coverage
Spatial:
United Kingdom,England,West Midlands
Typical Age Range:
16-100
Follow Up:
1 - 10 Years
Pathway:
Data is representative of the multi-ethnicity population within the West
Midlands (42% non white). Data includes all patients admitted during this
timeframe, with National data Opt Outs applied, and therefore is representative
of admissions to secondary care. Data focuses on in-patient stay in hospital
during the acute episode but can be supplemented on request to include previous
and subsequent hospital contacts (including outpatient appointments) and
ambulance, 111, 999 data.
Provenance
Origin
Purposes:
Care
Sources:
EPR
Collection Situations:
Secondary care - Accident and Emergency
Temporal
Accrual Periodicity:
Quarterly
Distribution Release Date:
17 November 2023
Start Date:
14 February 2017
End Date:
06 October 2022
Time Lag:
1-2 months
Accessibility
Access
Access Service:
Trusted Research Environments (TRE) are built using Microsoft Azure services and
hosted in the UK to provide research teams a safe, secure and agile environment
which allows users to quickly analyse, interpret and form an enriched view of
primary care information through a range of integrated datasets. Health data
collated from multiple sources is ingested into a secure data lake which will
then allow subsets of data to be made available to research teams on approval of
a data request. Once approved a customer specific TRE is made available with a
standard set of leading analytical tools from Microsoft including Azure
Databricks, Azure Machine Learning, Azure SQL and Azure Synapse (for large-scale
data warehouses). Specific tools can be provided at an additional cost over the
standard platform data access charge and the PIONEER team will work with you to
determine your exact needs. Access to the TRE is managed using the latest
virtual desktop technology to provide a safe and secure end-user experience. By
utilising leading edge design PIONEER are able to create TREs rapidly to enable
us to service any customer requirement.
Access Request Cost:
www.pioneerdatahub.co.uk/data/data-services-costs/
Delivery Lead Time:
Not applicable
Jurisdictions:
GB-ENG
Data Controller:
University Hospitals Birmingham NHS Foundation Trust
Usage
Data Use Limitations:
General research use
Data Use Requirements:
Project-specific restrictions
Resource Creators:
This publication uses data from PIONEER, an ethically approved database and analytical environment (East Midlands Derby Research Ethics 20/EM/0158)
Format and Standards
Vocabulary Encoding Schemes:
- SNOMED CT
- ICD10
Conforms To:
LOCAL
Languages:
en
Formats:
SQL
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
552 distinct patients admitted in ICU with sepsis, acute respiratory failure (specifically ARDS) or polytrauma without severe head injury
and with at least one measurement of NT-proBNP
552
Count
01 November 2022