Version: 1.0.0 | Published: 17 Mar 2026 | Updated: 13 days ago
Summary
DOI Name:
10.64898/2026.02.19.26346618
Documentation
Description:
The Human Genotype-Phenotype Map (GPMap) is an integrated discovery engine designed to bridge the gap between GWAS discovery and functional follow-up. While standard browsers identify genes in proximity to lead SNPs, the GPMap uses rigorous fine-mapping and colocalization to identify causal links between thousands of complex traits and molecular layers (eQTL, pQTL, sQTL, and methQTL).
Core Capabilities
Causal Locus Resolution: Transition from nearest gene heuristics to empirical evidence. By scanning Colocalization Groups (CGs), you can identify the specific phenotypes and molecular mechanisms sharing a genetic architecture at a single locus.
Systemic Pleiotropy & Comorbidity: Instantly visualize pleiotropic neighbors. The GPMap allows you to deconvolve whether a variant affects multiple traits independently (horizontal pleiotropy) or acts through a molecular mediator like a protein (vertical pleiotropy).
Precision MR Instruments: Streamline Mendelian Randomization by selecting instruments backed by high colocalization posterior probabilities (H4>0.8). This minimizes LD-contamination and ensures your IVs are functionally relevant.
User-Led Extensibility: Beyond our library of 4,500+ traits, you can upload your own GWAS summary statistics. The platform will automatically run fine-mapping and colocalization against our entire multi-omic database to identify supported mechanisms for your novel hits.
Coverage
Spatial:
European Ancestry
Typical Age Range:
1-150
Follow Up:
Other
Provenance
Origin
Purposes:
Other
Sources:
Other
Collection Situations:
Other
Temporal
Accrual Periodicity:
Irregular
Start Date:
22 February 2026
Time Lag:
Not applicable
Accessibility
Access
Access Rights:
Access Service:
The University grants you a non-exclusive, non-transferable revocable licence to
access and use the Platform for private or non-commercial research purposes
only.
Access Request Cost:
Free
Delivery Lead Time:
Not applicable
Data Controller:
NIHR Bristol Biomedical Research Centre
Data Processor:
NIHR Bristol Biomedical Research Centre
Usage
Data Use Limitations:
- General research use
- Not for profit use
Data Use Requirements:
Not for profit use
Resource Creators:
Univsersity of Bristol
Format and Standards
Vocabulary Encoding Schemes:
OTHER
Conforms To:
OTHER
Languages:
en