Version: 1.0.0 | Published: 9 Apr 2024 | Updated: 456 days ago
Documentation
Associated Media:
Description:
The Moorfields AMD Dataset is a longitudinal dataset consisting of routinely collected imaging and clinical metadata from patients receiving treatment for age-related macular degeneration (AMD) at Moorfields Eye Hospital NHS Foundation Trust, from 2004 to the present.
This dataset encompasses all patients at Moorfields Eye Hospital NHS Foundation Trust - a leading provider of eye health services in the UK and a world-class centre of excellence for ophthalmic research and education - who have received at least one injection of either Lucentis (ranibizumab) or Eylea (aflibercept). These therapies began at Moorfields in 2007, however, the dataset will include any imaging or clinical metadata that is available for these patients prior to that time (for example in patients who were initially monitored for the early or intermediate forms of this disease prior to receiving treatment). Also of note, this dataset will include data from both eyes in each case - for example, it will include data from fellow eyes that are not receiving injections. For these reasons, the dataset will include longitudinal data from a mixture of eyes with both “dry” and “wet” AMD.
Clinical metadata includes demographic information, visual acuities (predominantly measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts), diabetic retinopathy grading, and information regarding intravitreal therapies and ocular surgeries.
Imaging metadata includes colour fundus photographs, optical coherence tomography (OCT) scans (Topcon, Heidelberg), fundus autofluorescence (Heidelberg), fluorescein and indocyanine green angiography (Heidelberg).
This dataset is continuously updated. As of September 2021, it consisted of 11,001 eyes receiving Lucentis or Eylea for AMD, 176,370 injection episodes, and 1,989,711 ophthalmic images. This is the largest single centre database from patients with AMD and covers more than a decade of follow-up for these patients.
Is Part Of:
Not Applicable
Coverage
Typical Age Range:
49-101
Follow Up:
> 10 YEARS
Physical Sample Availability:
OTHER
Pathway:
The dataset is representative of the entire pathway for patients receiving
treatment for age-related macular degeneration (AMD) at Moorfields Eye Hospital
NHS Foundation Trust
Provenance
Origin
Purposes:
STUDY
Sources:
- EPR
- MACHINE GENERATED
- OTHER
Collection Situations:
- ACCIDENT AND EMERGENCY
- CLINIC
- IN-PATIENTS
- OUTPATIENTS
Temporal
Accrual Periodicity:
CONTINUOUS
Time Lag:
1-2 WEEKS
Accessibility
Access
Access Rights:
Access Service:
INSIGHT is developing its data access environment for researchers. INSIGHT
releases anonymised data, under strict data licence arrangements, to external
secure environments, subject to appropriate due diligence and contracting.
Access Request Cost:
Delivery Lead Time:
2-6 MONTHS
Jurisdictions:
GB-GBN
Data Controller:
Moorfields Eye Hospital NHS Foundation Trust
Data Processor:
Not Applicable
Usage
Data Use Limitations:
GENERAL RESEARCH USE
Data Use Requirements:
PROJECT SPECIFIC RESTRICTIONS
Resource Creators:
Is Referenced By:
Format and Standards
Vocabulary Encoding Schemes:
- DM+D
- NHS NATIONAL CODES
- SNOMED CT
Conforms To:
- NHS DATA DICTIONARY
- OTHER
Languages:
en
Formats:
- CSV
- Image
Enrichment and Linkage
Qualified Relations:
None
Derivations:
Not Applicable
Observations
Statistical Population
Population Description
Population Size
Measured Property
Observation Date
Persons
8,692 Patients
17,027 Eyes with 1,989,711 Images
11,001 Eyes with 176,370 Injections (Lucentis/Eylea)
17,379 Eyes with 513,619 Visual Acuity readings
8692
Patients
01 January 2021